A disorder characterized by advanced bone age
at birth, broad forehead, prominent eyes, and small chin. There is difficulty feeding,
failure to thrive, retarded psychomotor development, and predisposition to respiratory
infection. It may be fatal within the first years of life. The cause of the syndrome
is unknown. It is named for Richard E. Marshall and David W. Smith who were the
lead and last authors, respectively, of the first description of the syndrome in
1971. It shares some features with a condition called Weaver syndrome.
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