< b>Kashin-Beck disease: A disorder of the bones and joints of the hands
and fingers, elbows, knees, and ankles of children and adolescents who slowly develop
stiff deformed joints, shortened limb length and short stature due to necrosis (death)
of the growth plates of bones and of joint cartilage. The disorder is endemic in
some areas of eastern Siberia, Korea, China and Tibet and is probably of environmental
origin, as evidenced by the fact that it occurs in children who move into the endemic
areas and children with it who move away get better. Selenium supplementation has
no effect on established Kashin-Beck disease. Iodine deficiency should be corrected.
It is clearly a factor in the disease. Also called Kashin-Bek disease. The people
in the areas subject to the disorder called it big bone disease.
Common Misspellings: kashin-beck diease, kashin-beck desease
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