Due to little whit e (or lightly colored) spots that are
slightly elevated on the surface of the iris. These spots, arranged in a ring concentric
with the pupil, occur in normal children but are far more frequent in Down's syndrome
(trisomy 21). They were described in 1924 by Thomas Brushfield, are called Brushfield's
spots, and are due to aggregation of a normal iris element (connective tissue).
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