A mobile DNA element that can capture and carry genes, particularly
those responsible for antibiotic resistance. Integrons do this by site-specific
recombination.
T here are at least three classes of integrons based upon which integrase gene
they contain. The antibiotic resistance genes that integrons capture are located
on gene cassettes. These cassettes can exist as free circular DNA. A recombination
event occurs, integrating the cassette into the integron. Additional gene cassettes
can integrate, resulting in the integration of several genes.
Although gene cassettes are a mechanism for the development of multiple antibiotic
resistance, bacteria predating the use of antibiotics have also been found to contain
cassettes.
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