Inbreeding, coefficient of definition - medical term
A measure of how close
two
people are genetically to each another. The coefficient of
inbreeding, symbolized by the letter F, is the probability that a
person with two identical genes received both genes from one
ancestor.
Take a first-cousin mating. First cousins share a set of
grandparents. For any particular gene in the male, the
chance that his female first cousin inherited the same gene from the
same source is 1/8. Further, for any gene the man passes to his
child, the chance is 1/8 that the woman has the same gene and ½ that
she transmits that gene to the child so 1/8 X ½ = 1/16. Thus, a
first-cousin marriage has a coefficient of inbreeding F =1/16.
The added risks for the offspring of first cousins depend not only
upon the coefficient of inbreeding but also upon the genetic family
history and test results. For example, first cousins of Italian
descent are at increased risk of carrying a gene
for beta thalassemia and genetic laboratory tests may confirm that
they are both beta-thalassemia gene carriers.
There are always added risks in the mating of closely related
persons and those risks are not entirely negligible.
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