International normalized ratio, a system established by the World
Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis
for reporting the results of blood coagulation (clotting) tests. All results are
standardized using the international sensitivity index for the particular thromboplastin
reagent and instrument combination utilized to perform the test.
F or example, a person taking the anticoagulant ("blood thinner") warfarin (brand
name: Coumadin) might optimally maintain a prothrombin time (a "pro time" or PT)
of 2 to 3 INR. No matter what laboratory checks the prothrombin time, the result
should be the same even if different thromboplastins and instruments are used. This
international standardization permits the patient on warfarin to travel and still
obtain comparable test results.
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