A genetic skin disease that is characterized by scaly
(fishlike) areas of skin. The first scaly skin problems usually appear after 3 months
of age. The palms and soles are often affected. Areas that tend to be spared include
the axillae (the armpits), the antecubital fossa (the inside area at the bend of
the elbow) and the popliteal fossa (behind the knee).
A significant proportion of people with this disease have asthma, eczema or hay
fever.
The gene responsible ichthyosis vulargaris has been mapped to chromosome band
1q21. The product of this gene is a substance called filaggrin (abbreviated FLG)
which may act as the "keratin matrix protein" in cells of the stratum corneum, one
of the layers of the skin.
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