The abnormal placement of organs due to failure to establish the normal left-right patterning during embryonic development. The morbidity (disease) and mortality (death) from heterotaxy are caused by congenital defects, especially congenital heart disease.
M
utations in the zinc finger transcription factor ZIC3 cause an X-linked form of heterotaxy and have also been identified in patients with isolated congenital heart disease.
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