Hershey-Chase experiment definition - medical term
An extraordinarily important experiment in 1952
that helped to convince the world that DNA was the genetic material. Alfred Hershey
(1908-1997) and his assistant Martha Chase (1923-2003) at the Cold Spring Harbor
Laboratory showed that the DNA, not the protein, of the phage virus contains the
phage genes. After a phage particle attaches to a bacterium, its DNA enters through
a tiny hole while its protein coat remains outside. Key to the success of the experiment
was showing that viral infection was unaffected by violent agitation in a kitchen
blender (a Waring Blendor) which removed the empty viral protein shells from the
bacterial surface. The Hershey-Chase experiment became known as the "blender experiment."
A lfred D. Hershey won a Nobel Prize for his insights into the nature of viruses
in 1969, along with Max Delbrück and Salvador Luria. In a 1997 memoriam to Hersey,
James Watson wrote that "the Hershey-Chase experiment had a much broader impact
than most confirmatory announcements and made me ever more certain that finding
the three-dimensional structure of DNA was biology's next important objective. The
finding of the double helix by Francis Crick and me came only 11 months after my
receipt of a long Hershey letter describing his blender experiment results."
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