Hereditary mixed polyposis syndrome definition - medical term
(HMPS) A cancer family syndrome characterized
by the development of a variety of different types of polyps in the colon, including
atypical juvenile polyps and adenomas of the colon, and by the development of colorectal
carcinoma (cancer of colon and rectum). HMPS is inherited in an autosomal dominant
manner. The HMPS gene locus is on chromosome 15 in region 15q13-q14. HMPS is also
known as colorectal adenoma and carcinoma 1 (CRAC1).
I t has been uncertain whether HMPS is a distinct disorder or a variant of an
established disease called juvenile polyposis. The odds currently appear in favor
of it being either a distinct disorder or a genetically distinct form of juvenile
polyposis since the genes known to cause juvenile polyposis are in chromosomes 10q22.3
and 18q21.1.
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