A female carrying a mutant gene for hemophilia on
one of her two X chromosomes and a normal allele on her other X chromosome. Hemophilia
carriers have concentrations of clotting factor VIII or IX of about 50% of normal
and, hence, decreased coagulability. However, if they have a clinical bleeding tendency,
it is usually very mild.
H emophilia carriers are less likely to die from heart disease than noncarrier
women, probably due to their decreased blood clotting which, in turn, makes blockage
of their coronary arteries less likely. This is similar to the effect obtained by
taking aspirin.
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