A genomic crisis due to an extraordinarily high rate
of mutation, a phenomenon known to occur in viruses and perhaps in other organisms.
F or example, the antiviral agent Ribavirin acts by inducing genomic meltdown.
The drug accelerates the already-high mutation rate of RNA viruses, creates a genomic
crisis, and destroys the infectivity of the virus.
There is a limit to how much variation a genome can tolerate without irretrievably
degrading its genetic information. If a population of viruses is replicating at
the brink, just a bit of extra pressure from a mutagen, such as ribavirin, can nudge
it into the abyss of genetic meltdown, resulting in an inability for it to replicate
and survive.
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