A remarkable phenomenon in which a genetic disease
appears earlier appearance and with increased from with each succeeding generation.
Anticipation was once thought not to exist in genetics. It was chalked off as a
meaningless statistical artifact. However, anticipation has now been proven to occur
in a large number of important genetic disorders, including Huntington disease and
myotonic dystrophy. In molecular terms, anticipation is due to the expansion of
a trinucleotide repeat sequence in the DNA. This phenomenon also occurs in the fragile
X syndrome, the most common inherited form of mental retardation.
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