Genes, breast cancer susceptibility definition - medical term
Inherited factors that predispose
to b reast cancer. Put otherwise, these genes make one more susceptible to the disease
and so increase the risk of developing breast cancer. Two of these genes, BRCA1
and BRCA2, have been identified (and prominently publicized). Several other genes
(those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia)
are also known to predispose to breast cancer. However, since all of these known
breast cancer susceptibility genes together do not account for more than a minor
fraction (1/5th at most) of breast cancer that clusters in families,
it is clear that more breast cancer genes remain to be discovered. See related entries
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