The positive effect on gene freq uency when a population
(a colony) has only a small number of original settlers (founders) one or more of
whom had that gene. For example, the gene for Huntington disease was introduced
into the Lake Maracaibo region in Venezuela early in the 19th century. So there
are now over a hundred persons with Huntington disease and at least 900 persons
at risk for that deadly disease in that region, the largest known aggregation with
the Huntington gene in the world.
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