A gene that helps make a leukotriene, a signal that activates the
white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating
protein.
F LAP has been implicated in a number of inflammatory responses, including asthma,
arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered
to be a major risk factor for the common form of heart attack and the second major
genetic factor identified in the common form of stroke.
Also known, confusingly, as 5-lipoxygenase activating protein, five-lipoxygenase-activating
protein, five-lipoxygenase activating protein, arachidonate 5-lipoxygenase-activating
protein, arachidonate 5-lipoxygenase activating protein, and ALOX5AP.
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