Fever of unknown origin (FUO) is a fever greater
than 38.3°C (101 °F) that has occurred intermittently for over three weeks, for
which no specific cause readily identified.
In 8 5 to 95% of cases, the specific cause for a fever of unknown origin can
eventually be identified after extensive diagnostic testing. The causes of a fever
of unknown origin that are eventually discovered typically fall into one of three
categories: uncommon infections, cancers, and chronic inflammatory diseases (most
commonly connective tissue diseases or autoimmune diseases).
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