An autosomal dominant condition characterized by
an abnormally high level of eosinophils in the blood. Despite the prolonged eosi
nophilia, there may be no symptoms. The gene for familial eosinophilia, called EOS,
has been mapped to chromosome region 5q31-33 containing the cytokine gene cluster
which includes the genes for interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte
colony-stimulating factor (G-CSF), and all of which are thought play roles in the
development, proliferation, and activation of eosinophils.
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