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Definition of Familial cylindromatosis
Familial cylindromatosis definition - medical term
A genetic syndrome in which numerous benign
tumors of skin adn exa (such as the sweat glands) develop, principally on the head
and neck. This disorder is inherited in an autosomal manner and is caused by mutation
of the CYLD gene on chromosome 16q12-q13. Mutation of CYLD has been likened to having
faulty brakes on a car. Instead of a pileup of cars, a pileup of cells results.
Topical application of aspirin, another type of brake on cell proliferation, may
possibly be useful. Also called the turban tumor syndrome.
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