A coagulation factor, a substance in blood essential to the
normal clotting process. Production of factor X takes place in the liver and requires
vitamin K. The gene for factor X is located on chromosome 13 and is in band 13q34.
T he "X" in factor X is the Roman numeral "ten." (All numbered coagulation factors
bear Roman numerals.) Factor X became known because of a genetic condition in which
the factor is lacking.
Factor X deficiency is inherited as an autosomal recessive trait manifest by
prolonged nose bleeds, gastrointestinal hemorrhage, menorrhagia (abnormally heavy
menstrual bleeding), hematuria (blood in the urine), and hemarthrosis (bleeding
into joints). Pregnancy in women with factor X deficiency is often associated with
adverse fetal outcomes (recurrent spontaneous abortion, placental abruption, and
premature birth).
Factor X is also called Stuart-Prower factor because Mr. Stuart and Miss Prower
were the first persons shown to have deficiency of this factor.
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