A population group with an unusual frequency of a gene
due to there having been only a small number of original members ("founders") one
or more of whom had that gene. For example, the gene for Huntington disease was
introduced into the Lake Maracaibo region of Venezuela early in the 19th
century, so there are now over a hundred persons with Huntington disease and at
least 900 persons at risk for that deadly disease in that region, the largest known
aggregation known in the world with the Huntington gene.
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