A disease that interferes with the ability to work,
sleep, eat, and enjoy once pleasurable activities.
T he signs and symptoms of major depression include loss of interest in activities
that were once interesting or enjoyable, including sex; loss of appetite (anorexia)
with weight loss or overeating with weight gain; loss of emotional expression (flat
affect); a persistently sad, anxious or empty mood; feelings of hopelessness, pessimism,
guilt, worthlessness, or helplessness; social withdrawal; unusual fatigue, low energy
level, a feeling of being slowed down; sleep disturbance with insomnia, early-morning
awakening, or oversleeping; trouble concentrating, remembering, or making decisions;
unusual restlessness or irritability; persistent physical problems such as headaches,
digestive disorders, or chronic pain that do not respond to treatment; thoughts
of death or suicide or suicide attempts. Alcohol or drug abuse may be signs of depression.
Disabling episodes of major depression can occur once or a number of times in
a lifetime.
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