CCD (cleidocranial dysostosis) definition - medical term
A ge netic (inherited) disorder of bone
development characterized by:
Absent or incompletely formed collar bones (the "cleido-" part refers to
the clavicles, the collar bones) The child with this disorder can bring its
shoulders together or nearly so.
Typical cranial and facial abnormalities with square skull, late closure
of the sutures of the skull, late closure of the fontanels (the soft spots),
low nasal bridge, delayed eruption of the teeth, abnormal permanent teeth, etc.
The disorder is transmitted in an autosomal dominant manner. A parent with the
condition has a 50:50 chance that each of their children will have the condition.
Boys and girls stand an equal chance of being affected. The gene for the condition
has been found on chromosome 6 (specifically, in band p21). The gene is for the
transcription factor CBFA1 (core-binding factor alpha subunit 1). Mutations of CBFA1
cause this disorder.
A possible example of this disorder has been found in the skull of a Neanderthal
man.
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