A disorder of lymphoid tissue (lymphadenopathy) with
massive overgrowth (hyperplasia) of lymph nodes ("swollen glands"), most commonly
affecting the nodes between the lungs (in the mediastinum).
T here are two quite different forms of Castleman disease. One form, found in
90% cases, is a localized kind of lymphadenopathy. It usually causes no symptoms,
follows an indolent (lazy) course and can be cured simply by excision (surgical
removal).
The far more ominous form of Castleman disease, encountered in 10% of cases,
is a multicentric lymphadenopathy with progressive systemic signs and symptoms such
as fever and anemia. This rapidly progressive multicentric type of Castleman disease
is associated with infection by human herpesvirus 8 (HHV-8).
The disease was first described by B. Castleman and colleagues in 1956.
Common Misspellings: castleman diease, castleman desease
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