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Definition of C-peptide
C-peptide definition - medical term
A byproduct of insulin production, usually by the pancreas.
The level of C-peptide is a gauge of how much insulin is being produced in the body.
C-peptide is made up of chemical compounds called amino acids. When the pancreas
produces insulin, it releases C-peptide into the bloodstream in the same way that
the production of heat from burning coal or wood releases smoke into the atmosphere.
The amount of C-peptide in the blood can indicate the presence or absence of
disease. For example, abnormally low amounts of C-peptide in the blood suggest the
insulin production is too low (or absent) because of type I diabetes, also known
as juvenile or insulin-dependent diabetes. Abnormally high amounts of C-peptide
warn of the possible presence of a tumor called an insulinoma that secretes insulin.
Normal levels of C-peptide may signal that all is well. However, in a person
with diabetes, a normal level of C-peptide indicates the body is making plenty of
insulin but the body is just not responding properly to it. This is the hallmark
of type 2 diabetes (adult insulin-resistant diabetes). C-peptide, therefore, plays
a crucial diagnostic role as regards insulin.
Insulin is a hormone that regulates the body's use of glucose (blood sugar).
Muscle cells and other types of cells need glucose to generate energy. The body
manufactures glucose from food, mainly carbohydrates. It is the job of insulin to
deliver glucose to an energy-consuming body site. There it knocks on the front door
and places the glucose into the hands of the occupant. The occupant then uses the
glucose to help its master -- the body -- walk, run, throw, lift, and carry out
other activities. Football players, mountain climbers and lumberjacks all thrive
on the energy glucose provides. Insulin also prevents glucose overload in the bloodstream
by lowering the level of blood glucose as necessary. Insulin is released by cells
in the pancreas called the islets of Langerhans.
If the pancreas malfunctions, it may produce an inadequate supply of insulin,
or no insulin at all. Blood sugar then increases because there is little or no insulin
to regulate it. Type 1 diabetes then develops. Meanwhile, the reduced production
of insulin also reduces the amount of C-peptide released into the bloodstream. If
a patient reports symptoms of diabetes to a physician--symptoms that may include
great thirst, frequent urination and fatigue--the physician can order a test that
checks for the amount of C-peptide in the blood. If a patient reports symptoms consist
with pancreatic cancer -- abdominal pain, cramps, weight loss, and jaundice-- the
physician can again order the C-peptide test -- to determine the likelihood of a
tumor.
"Peptide" is derived from the Greek word "peptein" (to digest). Another term
derived from "peptein" is "peptic ulcer" (stomach ulcer).
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