Acrodermatitis enteropathica definition - medical term
An historic model for the therapy of genetic
disease. In an era (the 1950s) when inherited disorders were usually seen as hopeless,
this progressive hereditary (autosomal recessive) disease of children was found
treatable. Acrodermatitis enteropathica is characterized by the simultaneous occurrence
of skin inflammation (dermatitis) and diarrhea. The skin on the cheeks, elbows and
knees and tissue about the mouth and anus are inflamed. There is also balding of
the scalp, eyebrows and lashes, delayed wound healing and recurrent bacterial and
fungal infections due to immune deficiency.
The key laboratory finding in acrodermatitis enteropathica is an abnormally low
blood zinc level, reflecting impaired zinc uptake. Treatment with zinc by mouth
is curative.
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