A skin condition characterized by dark thickened
velvety patches, especially in the folds of skin in the axilla (armpit), groin and
back of the neck. The condition is complex. It can occur with endocrine diseases
such as Cushing disease, tumors of the pituitary, and diabetes mellitus. It is common
in people who have insulin resistance -- whose body is not responding correctly
to the insulin that they make in their pancreas. Acanthosis nigricans also occurs
with underlying malignancies (especially carcinomas of the vicera), administration
of certain drugs, and as a genetic disorder inherited in an autosomal dominant manner.
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